Barcelona itself is having some sort of problem, the last time they face a tough opposition (Madrid) they failed miserably. This is a cup they failed to win for some time now, that also will not adda any confidence to the bunch. But the most significant factor might be their hero of earlier victory against Sevilla, Lionel Messi is missing. But still they can produce excellent football. If last match is some indication, I believe Henry is slowly gelling with the side. Bojan needs to start ahead of Giovanni as I think he has more energy to offer. Edmillson should take Toure's position.
The main question in Rijkaard's mind will be "Whether I should go For a win?" - My answer will be employ a defensive strategy like last game and try to get out of there with a draw or worst a single goal loss. The two stage ties needs to be planned well.