Pizzuti used Twitter (pic) to ask fans which songs she should learn for Thursday's Europa League match with Napoli.
And after watching the Reds come from behind to win 3-1, she posted a string of tweets raving about the atmosphere.
"The 'You're not singing anymore' chant at the muted Napoli fans once we pulled ahead was a highlight..." she wrote.
Boston Red Sox owner Henry and real estate developer Pizzuti got married last year at the team's Fenway Park stadium when he was 59 and she was 30.
The couple had been in Liverpool since Tuesday before attending their first home match since Henry's New England Sports Ventures group completed their £300m takeover of the club.
Having tweeted on Tuesday that she was enjoying exploring the "cool city" of Liverpool, Pizzuti followed up on Wednesday with a plea to Reds fans.
"Studying up in the Anfield songbook to prepare for my first LFC match tomorrow night-can't wait! Aside from YNWA [club anthem You'll Never Walk Alone], what songs should I learn?," she wrote.
During the game, television cameras regularly captured the pair, with Henry seen shaking his head after Napoli took a first-half lead.
But they were soon celebrating with a raucous Anfield crowd as beloved skipper Steven Gerrard came off the bench to score a hat-trick.
Linda Pizzuti and John Henry soak up the Anfield atmosphere"Wow! Anfield really is a special place! Fantastic match (certainly heard the Gerrard song!) with first class and very fun supporters," Pizzuti tweeted on Thursday morning.
"And finally experiencing the famous Kop. Hearing, seeing, and feeling the massive force, spirit, and fun of it is incredible."
Pizzuti admitted she still has some way to go before becoming a true Koppite.
"Thank you for all of the song recommendations, sounds like "The Fields of Anfield Road" is my next lesson," she wrote. (bbc)