Soccer Extreme : The Reds saw a six-match undefeated run brought to an end with a 2-0 reversal at Stoke City last weekend, but they're able to boast a formidable home record against the Hammers and are unbeaten in the last 38 league meetings in front of the Kop.
West Ham will arrive on Merseyside rooted to the foot of the table. They're five points from safety and are without a Barclays Premier League victory since September.
However, Avram Grant's contingent have lost just twice in their last 11 outings in all competitions and have drawn each of their last three matches.
"It's always not easy to play at Anfield, especially when Liverpool need the points," said Grant.
"But we have lost just twice in 11 games, we want to continue with that and a little bit more.
"If we continue to do the right things - and there are things we could do better - the win will come and we will do everything to get it.
"Liverpool are a good team. They won three games in a row and played good football. They lost at Stoke but they could also have not lost there."
Grant concedes that while he will send his team out with the intention of winning, he could be satisfied with a point.
He said: "It depends on how the game goes. Sometimes, like when we went to Birmingham, we knew it was a very tough place to go because they had lost only one game, but we were disappointed with one point.
"I think in any game of football, situations occur where you can make surprises. This is our target, but we will see how the game goes. We want to win."
Grant added: "I enjoy it (the challenge of playing at Anfield). It is the first club that I came to when I was 20 or 21 - it was a long time ago! It was the first time I visited a team and I was at Anfield with Bob Paisley. I enjoyed it very much.
"Nobody can say more than what people already know about the history of Anfield. It's one of the temples of football and I enjoy going there, but I enjoy taking points there more."
Liverpool's central midfield options have been depleted ahead of West Ham's visit following injuries to Steven Gerrard and Jay Spearing, while Lucas Leiva will serve a one-match suspension.
Joe Cole and Daniel Agger also remain sidelined, but Fernando Torres, Glen Johnson, Dirk Kuyt and Martin Skrtel have all been declared fit for the 5.30pm kick-off.
West Ham have no fresh injury doubts following the midweek internationals, though they will be without Anthony Edgar, Peter Kurucz, Thomas Hitzlsperger, Jack Collison and Zavon Hines, while Tal Ben Haim, Valon Behrami and Manuel da Costa are said to be doubtful. (espn)